[Study on effects of oral administrating of silybum marianum [L.] gaertn. extract [silymarin] on biochemical factors and tissue changes caused by aflatoxin in broiler chickens]

In poultry industry the most common and important mycotoxin is aflatoxin, and decreasing its economical and sanitary damages by using effective and inexpensive substances is the target of most of the researchers. Since the pathologic effects of aflatoxin toxicity are more important in liver, kidney and muscles, and due to the mechanism of formation of the damages and also taking in to account the other studies on silymarin effects [extract of Silybum marianum] in preventing various liver and kidney diseases, the silymarin effects reviewed on preventing the losses caused by aflatoxin due to the poultry breeding farms conditions in Iran. In this study 56 one-day chicken, divided in to 4 groups, each group contains 14 chickens. First group were feed with normal allotment, second group with normal allotment with added 1 mg/Kg aflatoxin, third group with normal allotment with 800 mg silymarin per kg body weight and with added 1 mg/Kg aflatoxin, and after 42 days biochemical, autopsy and histopathology surveys have been done on the samples. According to the reviewed data and comparing the results of studied groups, silymarin can be recommended for decreasing the damages caused by aflatoxin during the period of breeding broiler chickens

Study on effects of topical use of Silybum marianum extract [silymarin] on U.V. irradiated guinea pig skin

Regarding to the skin damages caused by the ultraviolet ray of sun and the need for protective materials against these mal effects, Silymarin was evaluated for the porpose. In this study, by histopathology studies and surveying the clinical symptoms the external use of an herbaceous [herbal] substance, Silymarin, in protecting the mal effects of ultraviolet ray has been evaluated. For the study 60 albino hamsters with same age and gender has been selected and they divided in two groups [each group 30 hamsters] randomly. The hair on the back of all animals shaved in an area about 2 square centimeters. The first group gets 9 miligram Silymarin with 20 micro liter acetone topically, and the second group gets only 20 micro liter acetone topically. Then both groups for 45 days exposed to ultra violet ray, 180 milijoule/cm[2] each day. The results of clinical and histopathologic surveys show that topical usage of Silymarin has considerable protective effects against the mal effects of ultra violet ray on skin and this can be a promise for using this herbaceous substance as a topical sun protects substance